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Pharmacotherapeutic Group: Antibacterial (Semisynthetic cephalosporin Antibiotic).
Pharmacology: Pharmacodynamics: Mechanism of action: Bactericidal action of cefixime results from inhibition of cell-wall synthesis.
Pharmacokinetics: Cefixime, given orally is about 40% - 50% absorbed whether administered with or without food; however, time to maximal absorption is increased approximately 0.8 hours when administered with food. A single 200 mg tablet of cefixime produces an average peak serum concentration of approximately 2 mcg/ml (range 1 to 4 mcg/ml). Peak serum concentrations occur between 2 and 6 hours following oral administration of a single 200 mg tablet. Approximately 50% of the absorbed dose is excreted unchanged in the urine in 24 hours. The serum half-life of cefixime in healthy subjects is independent of dosage form and averages 3.0-4.0 hours but may range up to 9 hours in some normal volunteers. There is no evidence of metabolism of cefixime in vivo.
